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Showing 1 - 20 of 93 Items
Showing 1 - 20 of 93 Items
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Research

Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Van Anh DT,  et al.
2025-09-01 • Lancet Child and Adolescent Health
2025-09-01 • Lancet Child and Adolescent Health

BACKGROUND

Prognostic tools for febrile illnesses are urgently required in resource-constrained community contexts. Circulating immune and endothelial activatio...

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Research

External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB

Melingui B, 
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Conference Material
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Abstract
Conference Material
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Video

Impact of decentralisation of childhood TB diagnosis to district hospitals and primary health centers; Example from Uganda

Natukunda N
2023-06-08 • Epicentre Scientific Day Paris 2023
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Initial evaluation of a new cervical screening strategy combining human papillomavirus genotyping and automated visual evaluation: the Human Papillomavirus–Automated Visual Evaluation Consortium

Befano B, Kalpathy-Cramer J, Egemen D, Inturrisi F, Jeronimo J,  et al.
2025-03-18 • Journal of the National Cancer Institute
2025-03-18 • Journal of the National Cancer Institute

The HPV-Automated Visual Evaluation (PAVE) Consortium is validating a cervical screening strategy enabling accurate cervical screening in resource-limited settings. A rapid, low-cost ...

Risk stratification of childhood infection using host markers of immune and endothelial activation: A multi-country prospective cohort study in Asia (Spot Sepsis)

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Anh DTV,  et al.
2025-02-05 • medRxiv
2025-02-05 • medRxiv

BACKGROUND

Circulating markers of immune and endothelial activation risk stratify infection syndromes agnostic to disease aetiology. However, their utility in c...

The genetic diversity of Nipah virus across spatial scales

Cortes-Azuero O, Lefrancq N, Nikolay B, McKee C, Cappelle J,  et al.
2024-12-16 • Journal of Infectious Diseases
2024-12-16 • Journal of Infectious Diseases

BACKGROUND

Nipah virus (NiV), a highly lethal virus in humans, circulates in Pteropus bats throughout South and Southeast Asia. Difficulty in obtaining viral genomes from bats m...

Implementation of digital chest radiography for childhood tuberculosis diagnosis at district hospital level in six high tuberculosis burden and resources limited countries

Melingui BF, Basant J, Taguebue Jv, Massom DM, Leroy Terquem E,  et al.
2024-11-03 • Journal of Tropical Medicine
2024-11-03 • Journal of Tropical Medicine

OBJECTIVES

Chest x‐ray (CXR) plays an important role in childhood tuberculosis (TB) diagnosis, but access to quality CXR remains a major challenge in resource‐l...

Leroy-Terquem E, 
Taguebue J, 
Eap T, 
Borand L, 
et al.
2024-10-01 • IJTLD OPEN
2024-10-01 • IJTLD OPEN

Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study

d’Elbée M, Harker M, Mafirakureva N, Nanfuka M, Nguyet MHTN,  et al.
2024-03-21 • eClinicalMedicine
2024-03-21 • eClinicalMedicine

Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study

Wobudeya E, Nanfuka M, Ton Nu Nguyet MH, Taguebue JV, Moh R,  et al.
2024-03-21 • ACG Case Reports Journal
2024-03-21 • ACG Case Reports Journal
BACKGROUND
Childhood tuberculosis (TB) remains underdiagnosed largely because of limited awareness and poor access to all or any of specimen collection, molecular testing, clinical e...

Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB

Melingui BF, Leroy-Terquem E, Palmer M, Taguebue JV, Wachinou AP,  et al.
2024-02-01 • IJTLD OPEN
2024-02-01 • IJTLD OPEN
BACKGROUND
Chest X-ray (CXR) interpretation is challenging for the diagnosis of paediatric TB. We assessed the performance of a three half-day CXR training module for healthcare work...

Natural killer repertoire restoration in TB/HIV co-infected individuals experienced an immune reconstitution syndrome (CAMELIA Trial, ANRS 12153)

Pean P, Madec Y, Nerrienet E, Borand L, Laureillard D,  et al.
2023-10-13 • Pathogens
2023-10-13 • Pathogens
IRIS is a common complication in HIV-infected patients treated for tuberculosis (TB) and cART. Our aim was to evaluate NK cell reconstitution in HIV-infected patients with TB-IRIS compar...

Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: Experiences and perceptions from health care workers in Sub-Saharan Africa and South-East Asia

Joshi B, De Lima YV, Massom DM, Kaing S, Banga MF,  et al.
2023-10-11 • PLOS Global Public Health
2023-10-11 • PLOS Global Public Health
Decentralizing childhood tuberculosis services, including diagnosis, is now recommended by the WHO and could contribute to increasing tuberculosis detection in high burden countries. How...

Impact of decentralisation of childhood TB diagnosis to district hospitals and primary health centers; Example from Uganda

Natukunda N
2023-06-08 • Epicentre Scientific Day Paris 2023
2023-06-08 • Epicentre Scientific Day Paris 2023
BACKGROUND
Childhood tuberculosis is underdiagnosed at low-level healthcare settings because of poor access to specimen collection, rapid molecular testing, clinical evaluation and c...
2023-06-08 • Epicentre Scientific Day Paris 2023

Nurse-led initiation of hepatitis C care in rural Cambodia

O’Keefe D, Samley K, Bunreth V, Marquardt T, Bobi SE,  et al.
2023-04-01 • Bulletin of the World Health Organization
2023-04-01 • Bulletin of the World Health Organization
OBJECTIVE
To determine whether a nurse-led model of care for patients with hepatitis C virus (HCV) infections can provide safe and effective diagnosis and treatment in a resource-poo...

Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Marcy O, Wobudeya E, Font H, Vessière A, Chabala C,  et al.
2023-03-01 • Lancet Infectious Diseases
2023-03-01 • Lancet Infectious Diseases
BACKGROUND
Tuberculosis diagnosis might be delayed or missed in children with severe pneumonia because this diagnosis is usually only considered in cases of prolonged symptoms or ant...

Quality of antimalarials at the epicenter of antimalarial drug resistance: results from an overt and mystery client survey in Cambodia

Yeung S, Lawford H, Tabernero P, Nguon C, van Wyk A,  et al.
2015-06-01 • American Journal of Tropical Medicine and Hygiene
2015-06-01 • American Journal of Tropical Medicine and Hygiene
Widespread availability of monotherapies and falsified antimalarials is thought to have contributed to the historical development of multidrug-resistant malaria in Cambodia. This study a...

High sustained viral response rate in patients with hepatitis C using generic sofosbuvir and daclatasvir in Phnom Penh, Cambodia

Zhang M, O'Keefe D, Iwamoto M, Sann K, Kien A,  et al.
2020-05-02 • Journal of Viral Hepatitis
2020-05-02 • Journal of Viral Hepatitis
Safe and efficacious pan-genotypic direct-acting antiviral (DAA) regimens, such as sofosbuvir and daclatasvir (SOF+DCV) facilitate simplified models of care for hepatitis C virus (HCV). ...

How labour intensive is a doctor-based delivery model for antiretroviral treatment (ART)? Evidence from an observational study in Siem Reap, Cambodia

Van Damme W, Kheang ST, Janssens B, Kober K
2007-05-01 • Human Resources for Health
2007-05-01 • Human Resources for Health
BACKGROUND: Funding for scaling-up antiretroviral treatment (ART) in low-income countries has increased substantially, but the lack of human resources for health (HRH) is increasingly be...

Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome after early initiation of antiretroviral therapy in a randomized clinical trial

Laureillard D, Marcy O, Madec Y, Chea S, Chan S,  et al.
2013-10-23 • AIDS
2013-10-23 • AIDS
To analyze cases of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in the CAMbodian Early versus Late Introduction of Antiretrovirals (CAMELIA)...

Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis

Blanc FX, Sok T, Laureillard D, Borand L, Rekacewicz C,  et al.
2011-10-20 • New England Journal of Medicine
2011-10-20 • New England Journal of Medicine
Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiation...